Modern techniques for analyzing biological specimens produce large amounts of data describing gene expression, genome sequences, molecular structures, and molecular interactions. Researchers in the field of bioinformatics develop methods and tools to manage and make meaning of this data. Computational biologists use this data to better understand living systems, while researchers in translational bioinformatics apply these insights to efforts to improve human health.
Projects
- University of Kentucky Markey Cancer Center - Cancer Center Support Grant
- CAREER: Linking Structure, Stability and Protection in Protamine Packaged DNA
- Supplement: Cost Extension - Kentucky Center for Clinical and Translational Science
- CAREER: Developing Biochemoinformatics Tools for Large-Scale Metabolomics Applications
- Lung cancer in Appalachian Kentucky: Deciphering genetic influences
Recent publications and other works
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- journal article | 2020
- Machine learning and ligand binding predictions: A review of data, methods, and obstacles
- Biochimica et biophysica acta. General subjects
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- journal article | 2020
- Atom Identifiers Generated by a Neighborhood-Specific Graph Coloring Method Enable Compound Harmonization across Metabolic Databases
- Metabolites
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- journal article | 2020
- A chemical interpretation of protein electron density maps in the worldwide protein data bank
- PloS one
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- journal article | 2020
- GOcats: A tool for categorizing Gene Ontology into subgraphs of user-defined concepts
- PloS one
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- journal article | 2020
- Robust Moiety Model Selection Using Mass Spectrometry Measured Isotopologues
- Metabolites
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- journal article | 2020
- Deriving Lipid Classification Based on Molecular Formulas
- Metabolites
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- journal article | 2020
- MEScan: a powerful statistical framework for Genome-Scale mutual exclusivity analysis of cancer mutations
- Bioinformatics (Oxford, England)
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- journal article | 2020
- Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium
- Biochimica et biophysica acta. Molecular basis of disease
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- journal article | 2020
- SSIF: Subsumption-based Sub-term Inference Framework to audit Gene Ontology
- Bioinformatics (Oxford, England)