CANCELLED - Deciphering the regulatory code of metabolism in Arabidopsis - CANCELLED

Seung Yon (Sue) Rhee PhD

  • Senior Staff Member
  • Plant Biology Department, Carnegie Institution for Science, Stanford, CA

Nov 07, 2019|12:30 PM – 1:30 PM

Rhee 20191107

Coordinated control of metabolic genes is crucial for plant development and adaptation to various environments. To discover general rules of metabolic regulation, we used omics data, machine learning, and experimental validation. To understand how metabolic genes are controlled by epigenetic marks, we mapped regulatory patterns of 16 epigenetic marks across metabolism in Arabidopsis and found a predominant regulatory pattern for specialized metabolic genes involved in controlling the precise timing of gene expression upon stimuli. To understand how transcription factors regulate metabolism, we constructed condition- and tissue-specific regulatory networks in Arabidopsis and identified patterns of transcriptional regulation at various levels. These studies elucidate metabolism coordination and contribute to developing toolkits for pathway engineering in plants.

Seung Yon (Sue) Rhee is a Senior Staff Member of Plant Biology Department at Carnegie Institution for Science. Her group strives to uncover the molecular mechanisms underlying adaptive traits in the face of heat, drought, nutrient limitation, latitude and pests. Dr. Rhee's group studies a variety of plants including models, orphan crops, medicinal and desert plants. More recently their work has involved studying a model nematode C. elegans, fungal pathogens, corals, and piezophilic bacterium. Her group employs computational modeling and targeted laboratory testing to study mechanisms of adaptation, functions of novel genes, organization and function of metabolic networks, and chemical and neuronal code of plant-animal interactions. Her group is also interested in developing translational research programs involving carbon sequestration by plants and biomass maximization under drought in bioenergy crops. Dr. Rhee received her B.A. in biology from Swarthmore College and a Ph.D. in biology from Stanford University. She has been an investigator at the Plant Biology Department of Carnegie Institution for Science since 1999.